Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

The Individual Microbiologic Effect of Three Antimycobacterial Agents, Clofazimine, Ethambutol, and Rifampin, on Mycobacterium avium Complex Bacteremia in Patients with AIDS

Carol A. Kemper, Diane Havlir, Dennis Haghighat, Michael Dubé, Angie E. Bartok, Jeanette P. Sison, Yizhong Yao, Bienvenido Yangco, John M. Leedom, Jeremiah G. Tilles, J. Allen McCutchan and Stanley C. Deresinski
The Journal of Infectious Diseases
Vol. 170, No. 1 (Jul., 1994), pp. 157-164
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30133489
Page Count: 8
  • Download ($42.00)
  • Subscribe ($19.50)
  • Cite this Item
The Individual Microbiologic Effect of Three Antimycobacterial Agents, Clofazimine, Ethambutol, and Rifampin, on Mycobacterium avium Complex Bacteremia in Patients with AIDS
Preview not available

Abstract

The individual antibacterial activities of clofazimine, ethambutol, and rifampin in the treatment of Mycobacterium avium complex bacteremia in patients with AIDS were determined. Sixty human immunodeficiency virus 1-infected patients who had at least one blood culture positive for M. avium complex were randomized to receive either clofazimine (200 mg), etham-butol (15 mg/kg), or rifampin (600 mg) once daily for 4 weeks. Only ethambutol resulted in a statistically significant reduction in the level of mycobacteremia. The median change in individual baseline colony counts was 0.60 $log_10$ cfu/mL after 4 weeks of ethambutol (P = .046). In contrast, median changes in individual baseline colony counts were -0.2 $log_10$ cfu/mL and +0.2 $log_10$ cfu/mL for clofazimine and rifampin, respectively (both, P>. 4). Ethambutol had greater antibacterial activity, as determined by changes in the level of mycobacteremia, than either rifampin or clofazimine, supporting its continued use in combination with other agents in the treatment of M. avium infection.

Page Thumbnails

  • Thumbnail: Page 
157
    157
  • Thumbnail: Page 
158
    158
  • Thumbnail: Page 
159
    159
  • Thumbnail: Page 
160
    160
  • Thumbnail: Page 
161
    161
  • Thumbnail: Page 
162
    162
  • Thumbnail: Page 
163
    163
  • Thumbnail: Page 
164
    164