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Effect of the Combination of Interferon-α and Stavudine on Friend Virus Infections in (B10.A X A.By)F₁ Mice

Robert W. Sidwell, Reed P. Warren, Kevin Okleberry, Roger A. Burger and John D. Morrey
The Journal of Infectious Diseases
Vol. 171, Supplement 2. Treatment Trends in Human Immunodeficiency Virus Disease (Mar., 1995), pp. S93-S98
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30133580
Page Count: 6
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Effect of the Combination of Interferon-α and Stavudine on Friend Virus Infections in (B10.A X A.By)F₁ Mice
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Abstract

The anti-Friend leukemia virus (FLV) effects of interferon-α-A/D (IFN-α) and 2',3'-didehydro-2',3'-dideoxythymidine (stavudine) used alone and in combination were examined in Mus dunni cells using a checkerboard-type experiment design. Strong antiviral synergy and a suggested cytotoxic synergy were seen. In two experiments to evaluate the effect of combining therapy with IFN-α and stavudine against FLV disease in the hybrid mouse strain (B10.A X A.By)$F_1$, which is a strong producer of cytotoxic T cells, the drug combination resulted in better inhibition of FLV disease than did either drug used alone. Combination therapy inhibited splenomegaly, splenic virus infectious centers, plasma virus, and the virus-induced increase in hematocrit to a greater degree than did either drug alone. These data indicate that combination therapy with stavudine and IFN-α is effective in the treatment of murine retrovirus infections and may be of value in the treatment of human AIDS.

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