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Prevalence of IgM Antibodies to Human Herpesvirus 6 Early Antigen (p41/38) in Patients with Chronic Fatigue Syndrome

Madhumita Patnaik, Anthony L. Komaroff, Edward Conley, Emmanuel A. Ojo-Amaize and James B. Peter
The Journal of Infectious Diseases
Vol. 172, No. 5 (Nov., 1995), pp. 1364-1367
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30133783
Page Count: 4
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Prevalence of IgM Antibodies to Human Herpesvirus 6 Early Antigen (p41/38) in Patients with Chronic Fatigue Syndrome
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Abstract

To evaluate the association between human herpesvirus 6 (HHV-6) and chronic fatigue syndrome (CFS), 2 geographically separate groups of CFS patients (125 and 29 patients, respectively) and healthy controls (150 and 15 controls, respectively) were compared, using an EIA, for antibodies to HHV-6 early antigen p41Z38 (EA). Sixty percent (93/154) of CFS patients were positive for HHV6 EA IgM, 40% (61/154) were positive for IgG, and 23% (35/154) were positive for both. A total of 119 (119c) of the CFS patients were positive for HHV-6 EA IgG or IgM (or both); only 12% (20/165) of the controls had IgG or IgM to HHV-6 EA. These data demonstrate that more CFS patients than controls had elevated levels of HHV-6 EA-specific IgM, perhaps indicating active replication of HHV-6 in CFS.

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