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Fcγ Receptor IIa (CD32) Heterogeneity in Patients with Recurrent Bacterial Respiratory Tract Infections

Lieke A. M. Sanders, Jan G. J. van de Winkel, Ger T. Rijkers, Marleen M. Voorhorst-Ogink, Masja de Haas, Peter J. A. Capel and Ben J. M. Zegers
The Journal of Infectious Diseases
Vol. 170, No. 4 (Oct., 1994), pp. 854-861
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30134602
Page Count: 8
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Fcγ Receptor IIa (CD32) Heterogeneity in Patients with Recurrent Bacterial Respiratory Tract Infections
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Abstract

FcγRIIa (CD32) is the sole IgG Fc receptor capable of interaction with human IgG2, the main IgG subclass of bacterial capsular polysaccharides. The two genetically determined allotypes of human FcγRIIa, FcγRIIa-R131 and IIa-H131 alleles, have functionally different reactivities with human IgG2. The capacity of polymorphonuclear leukocytes (PMNL) homozygous for FcγRIIa-H/H131 for IgG2 opsonized bacteria is significantly higher than phagocytosis by PMNL homozygous for FcγRIIa-R/R131, independent of the FcγRIIIb-NA1/NA2 (CD16) allelic polymorphism. To test the clinical significance of these FcγR polymorphisms, FcγRIIa and FcγRIIIb phenotypes of 48 children with recurrent bacterial respiratory tract infections were determined. FcγRIIa-H/H131 was less than half that observed in 123 healthy adults (P = .01). IgG2 responses were low in 25 of 48 patients after immunization with pneumococcal vaccine. These results suggest that FcγRIIa polymorphism may contribute to increased susceptibility to infections with encapsulated bacteria in a childhood population with low IgG2 anti-carbohydrate antibodies.

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