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Divergent Human Papillomavirus Type 16 Variants Are Serologically Cross-Reactive

Grace Cheng, Joseph P. Icenogle, Reinhard Kirnbauer, Nancy L. Hubbert, Michael E. St. Louis, Chenglong Han, Edith I. Svare, Susanne Krüger Kjaer, Douglas R. Lowy and John T. Schiller
The Journal of Infectious Diseases
Vol. 172, No. 6 (Dec., 1995), pp. 1584-1587
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30134673
Page Count: 4
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Divergent Human Papillomavirus Type 16 Variants Are Serologically Cross-Reactive
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Abstract

It is not known whether DNA sequence variants of human papillomavirus type 16 (HPV-16) are distinct serotypes. To examine this question, the reactivities of women's sera from Zaire (n = 97) and Denmark (n = 123) were compared in IgG-specific ELISAs based on virus-like particles (VLPs) composed of the LI major capsid protein derived from an HPV-16 variant common in central Africa (Z-1194) or one common in northern Europe (114K). These Lis differ in seven amino acids. There was a strong correlation between reactivity in the two assays for both sets of sera (correlation coefficients, 0.73 and 0.85 for Zairian and Danish sera, respectively). In only 1 serum was there evidence for a specific reaction to one but not the other VLP variant. The results support the conclusion that the virions of strains Z-1194 and 114K are serologically cross-reactive.

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