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Brazilian Purpuric Fever Caused by Haemophilus influenzae Biogroup Aegyptius Strains Lacking the 3031 Plasmid

Maria Lucia Cecconi Tondella, Frederick D. Quinn and Bradley A. Perkins
The Journal of Infectious Diseases
Vol. 171, No. 1 (Jan., 1995), pp. 209-212
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30135421
Page Count: 4
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Brazilian Purpuric Fever Caused by Haemophilus influenzae Biogroup Aegyptius Strains Lacking the 3031 Plasmid
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Abstract

Brazilian purpuric fever (BPF) is a life-threatening pediatric infection caused by Haemophilus influenzae biogroup aegyptius (Hae), an organism formerly associated with only self-limited purulent conjunctivitis. Strains of Hae causing BPF have a 24-MDa plasmid with a specific AccI restriction pattern designated 3031. This plasmid was thought to code for a virulence factor because it had been detected only among Hae strains isolated from BPF cases or their contacts. From 3 typical BPF cases recently identified in São Paulo State, sterile-site Hae isolates were obtained; these isolates were similar to earlier BPF-associated Hae except they did not possess a 3031 plasmid. HindIII restricted chromosomal DNA from these strains was probed with purified 3031 plasmid DNA under high-stringency conditions. There was no evidence that 3031 plasmid DNA had become chromosomally integrated. It appears that the 3031 plasmid does not code for BPF-specific virulence factors.

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