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HEp-2 Cell-Adherent Escherichia coli in Patients with Human Immunodeficiency Virus-Associated Diarrhea

John J. Mathewson, Zhi Dong Jiang, Alimuddin Zumla, Chifumbe Chintu, Nkandu Luo, Suzanne R. Calamari, Robert M. Genta, Anita Steephen, Peter Schwartz and Herbert L. DuPont
The Journal of Infectious Diseases
Vol. 171, No. 6 (Jun., 1995), pp. 1636-1639
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30135596
Page Count: 4
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HEp-2 Cell-Adherent Escherichia coli in Patients with Human Immunodeficiency Virus-Associated Diarrhea
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Abstract

Diarrhea occurs commonly in African human immunodeficiency virus (HIV) infections. A case-control (HIV-positive vs. -negative) study of adults with diarrhea was done in Lusaka, Zambia, to determine the prevalence of intestinal infection by HEp-2 cell-adherent Escherichia coli. Adherent E. coli were more common in HIV-positive patients with acute diarrhea than among HIV-negative controls (60% vs. 33%) and were found significantly more often in HIV-positive patients with chronic diarrhea than among HIV-negative controls with chronic diarrhea (79% vs. 17%, P < .002). Adherent strains were found significantly more often among HIV-positive patients (69%) than in 22 asymptomatic subjects (36%, P < .02). The HEp-2 cell adherence of the E. coli strains did not show a common pattern. Adherent bacteria were also observed in colonic biopsies from 32% of Zambians with chronic diarrhea who underwent endoscopy. Adherent E. coli may be an important cause of HIV-associated diarrhea in Zambia.

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