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Bactericidal Activity for Neisseria meningitidis in Properdin-Deficient Sera

C. Söderström, J. H. Braconier, D. Danielsson and A. G. Sjöholm
The Journal of Infectious Diseases
Vol. 156, No. 1 (Jul., 1987), pp. 107-112
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30136512
Page Count: 6
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Bactericidal Activity for Neisseria meningitidis in Properdin-Deficient Sera
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Abstract

We investigated serum bactericidal reactions against Neisseria meningitidis (serogroups A, B, C, D, Y, W-135, 29E, X, and Z) in the sera of two healthy adults with properdin deficiency. Bactericidal reactions mediated via the classic complement pathway (unchelated system) were not impaired in properdin-deficient serum. The properdin-deficient sera supported alternative pathway-mediated killing (Mg⁺⁺EGTA-chelated system) of some, but not all, of the strains investigated. Vaccination of the properdin-deficient individuals with serogroup A and C polysaccharide clearly increased the concentrations of antibody to meningococci. At least some of the antibodies induced by vaccination supported the bactericidal activity of properdin-deficient serum. Some antibodies to meningococci, probably of the IgM class, promoted alternative pathway-mediated bactericidal reactions in the absence of properdin. By contrast, presensitizing meningococci with IgG enhanced the alternative pathway-mediated reactions, but this was strictly a properdin-dependent effect.

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