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Poliovirus Circulation among Schoolchildren during the Early Phase of the 1992-1993 Poliomyelitis Outbreak in The Netherlands
P. M. Oostvogel, H. C. Rumke, M. A. E. Conyn-van Spaendonck, H. G. A. M. van der Avoort, J. Leeuwenburg and A. M. van Loon
The Journal of Infectious Diseases
Vol. 184, No. 11 (Dec. 1, 2001), pp. 1451-1455
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30137237
Page Count: 5
You can always find the topics here!Topics: Children, Poliovirus, School age children, Infections, Viruses, Vaccination, Poliomyelitis, Neutralizing antibodies, Epidemics, Antibodies
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During the 1992-1993 outbreak of poliomyelitis in The Netherlands, we examined 866 children at 7 schools for evidence of infection with the outbreak virus, poliovirus type 3 (PV3), to determine the extent of the outbreak and the protection of the herd immunity. Seventy-seven children (8.9 %) showed evidence of recent wild-type PV3 infection, as determined by virus isolation and/or poliovirus type-specific IgM assay. Most infected children lived in the same area as the index case patient, attended an orthodox-reformed (OR) primary school, and had not been vaccinated. At the OR school, as many as 22 % of children immunized with inactive poliovirus vaccine were found to have evidence of recent infection, which is a significantly lower rate than that among unvaccinated children (59.5 %). No evidence of vaccination was seen in 25.5%-43.1% of children at OR schools. Seroprevalence of antibodies against the 3 types of poliovirus suggested that no poliovirus circulation had occurred between the 1978 and 1992-1993 outbreaks.
The Journal of Infectious Diseases © 2001 Oxford University Press