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Interleukin-2 Protects Neonatal Mice from Lethal Herpes Simplex Virus Infection: A Macrophage-Mediated, γ Interferon-Induced Mechanism

Steve Kohl, Lian Sim Loo, David B. Drath and Patricia Cox
The Journal of Infectious Diseases
Vol. 159, No. 2 (Feb., 1989), pp. 239-247
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30139371
Page Count: 9
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Interleukin-2 Protects Neonatal Mice from Lethal Herpes Simplex Virus Infection: A Macrophage-Mediated, γ Interferon-Induced Mechanism
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Abstract

Administration of human recombinant interleukin-2 (IL-2) protected neonatal mice from a lethal herpes simplex virus (HSV) infection. Protection was not associated with viral antibody production, enhanced natural killer cell cytotoxicity, or intrinsic resistance of macrophages to viral infection. Protection was associated with increased macrophage-mediated antiviral antibody-dependent cellular cytotoxicity (ADCC). Spleen cells from IL-2-treated neonatal mice and from neonatal mice that were treated in vitro with IL-2 transferred protection to neonatal mice. These cells, by adherence, silica, and asialo GM 1 antibody treatment, were shown to be macrophages. IL-2 treatment in vitro enhanced the neonatal macrophages, ADCC function and superoxide release. Similar protection was induced by γ interferon (IFN-γ)-treated spleen cells. Antibody to IFN-γ ablated both IFN-γ and IL-2-induced protection by adherent spleen cells. Thus, IL-2-mediated protection against murine neonatal HSV infection was affected by stimulated macrophage activity, via helper T cell-produced IFN-γ.

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