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Sperm-Associated Retroviruses in the Mouse Epididymis
Ann A. Kiessling, Richard C. Crowell and Ried S. Connell
Proceedings of the National Academy of Sciences of the United States of America
Vol. 84, No. 23 (Dec. 1, 1987), pp. 8667-8671
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/30527
Page Count: 5
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Sperm adsorbed with retrovirus particles were recovered from the epididymis of apparently normal male mice. Epididymal semen from all four mouse strains examined was positive for retrovirus (105 to 108 particles per μ g of protein) indicating that epididymal fluids and sperm may be important vehicles for murine retrovirus spread. Immunoblot analyses revealed that the banding patterns of electrophoretically separated epididymal viral proteins from the four strains of males were more similar to each other than to either xenotropic New Zealand Black virus or ecotropic Rauscher leukemia virus proteins. The results indicate that retrovirus particles, possibly a unique strain, are commonly expressed at relatively high titers in the reproductive tract of male mice and are sperm-associated.
Proceedings of the National Academy of Sciences of the United States of America © 1987 National Academy of Sciences