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Poly(ADP-Ribose) Polymerase-1 is Required for Efficient HIV-1 Integration
Hyo Chol Ha, Krishna Juluri, Yan Zhou, Steve Leung, Monika Hermankova and Solomon H. Snyder
Proceedings of the National Academy of Sciences of the United States of America
Vol. 98, No. 6 (Mar. 13, 2001), pp. 3364-3368
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/3055241
Page Count: 5
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Poly(ADP-ribose) polymerase-1 (PARP-1; EC 22.214.171.124) is an abundant nuclear enzyme, activated by DNA strand breaks to attach up to 200 ADP-ribose groups to nuclear proteins. As retroviral infection requires integrase-catalyzed DNA strand breaks, we examined infection of pseudotyped HIV type I in fibroblasts from mice with a targeted deletion of PARP-1. Viral infection is almost totally abolished in PARP-1 knockout fibroblasts. This protection from infection reflects prevention of viral integration into the host genome. These findings suggest a potential for PARP inhibitors in therapy of HIV type I infection.
Proceedings of the National Academy of Sciences of the United States of America © 2001 National Academy of Sciences