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L-Selectin Can Facilitate Metastasis to Lymph Nodes in a Transgenic Mouse Model of Carcinogenesis
Fawn Qian, Douglas Hanahan and Irving L. Weissman
Proceedings of the National Academy of Sciences of the United States of America
Vol. 98, No. 7 (Mar. 27, 2001), pp. 3976-3981
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/3055355
Page Count: 6
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L-selectin mediates homing of lymphocytes to lymph nodes (LN). Transgenic mice that express rat insulin promoter regulated simian virus 40 Tag (RIP-Tag) develop large, local cancers that metastasize to liver but not LN. To test whether this lack of LN metastases reflects their absence from the circulation, transgenic mice were produced that express Tag (T), L-selectin (L), and Escherichia coli LacZ (Z), in pancreatic β cells. LTZ mice developed insulinomas that specifically had LN metastases; metastasis was blocked by an anti L-selectin mAb. LacZ+ tumor cells from these LN homed to secondary LN upon transfer. These results suggest that the highly vascularized islet carcinomas are shedding tumor cells into the bloodstream, which is a necessary but insufficient condition for metastasis to occur; L-selectin can facilitate homing of such tumor cells to LN, resulting in metastasis.
Proceedings of the National Academy of Sciences of the United States of America © 2001 National Academy of Sciences