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Maximum of the Weighted Kaplan-Meier Tests with Application to Cancer Prevention and Screening Trials

Yu Shen and Jianwen Cai
Biometrics
Vol. 57, No. 3 (Sep., 2001), pp. 837-843
Stable URL: http://www.jstor.org/stable/3068423
Page Count: 7
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Maximum of the Weighted Kaplan-Meier Tests with Application to Cancer Prevention and Screening Trials
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Abstract

A class of maximum weighted Kaplan-Meier test statistics is described where the weight functions are chosen from a family of smooth functions. The investigated test statistic is robust and sensitive to a variety of alternatives that are often observed in cancer prevention and screening trials. A simulation study is performed to compare the size and power properties between the proposed test statistics and some existing ones. We illustrate the procedure using data from a clinical trial of a breast cancer screening program.

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