Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Gridlock, an HLH Gene Required for Assembly of the Aorta in Zebrafish

Tao P. Zhong, Michael Rosenberg, Manzoor-Ali P. K. Mohideen, Brant Weinstein and Mark C. Fishman
Science
New Series, Vol. 287, No. 5459 (Mar. 10, 2000), pp. 1820-1824
Stable URL: http://www.jstor.org/stable/3074602
Page Count: 5
  • More info
  • Cite this Item
Gridlock, an HLH Gene Required for Assembly of the Aorta in Zebrafish
Preview not available

Abstract

The first artery and vein of the vertebrate embryo assemble in the trunk by migration and coalescence of angioblasts to form endothelial tubes. The gridlock (grl) mutation in zebrafish selectively perturbs assembly of the artery (the aorta). Here it is shown that grl encodes a basic helix-loop-helix (bHLH) protein belonging to the Hairy/Enhancer of the split family of bHLH proteins. The grl gene is expressed in lateral plate mesoderm before vessel formation, and thereafter in the aorta and not in the vein. These results suggest that the arterial endothelial identity is established even before the onset of blood flow and implicate the grl gene in assignment of vessel-specific cell fate.

Page Thumbnails

  • Thumbnail: Page 
1820
    1820
  • Thumbnail: Page 
1821
    1821
  • Thumbnail: Page 
1822
    1822
  • Thumbnail: Page 
1823
    1823
  • Thumbnail: Page 
1824
    1824