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Docosahexaenoic Acid, a Ligand for the Retinoid X Receptor in Mouse Brain

Alexander Mata de Urquiza, Suya Liu, Maria Sjöberg, Rolf H. Zetterström, William Griffiths, Jan Sjövall and Thomas Perlmann
Science
New Series, Vol. 290, No. 5499 (Dec. 15, 2000), pp. 2140-2144
Stable URL: http://www.jstor.org/stable/3081610
Page Count: 5
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Docosahexaenoic Acid, a Ligand for the Retinoid X Receptor in Mouse Brain
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Abstract

The retinoid X receptor (RXR) is a nuclear receptor that functions as a ligand-activated transcription factor. Little is known about the ligands that activate RXR in vivo. Here, we identified a factor in brain tissue from adult mice that activates RXR in cell-based assays. Purification and analysis of the factor by mass spectrometry revealed that it is docosahexaenoic acid (DHA), a long-chain polyunsaturated fatty acid that is highly enriched in the adult mammalian brain. Previous work has shown that DHA is essential for brain maturation, and deficiency of DHA in both rodents and humans leads to impaired spatial learning and other abnormalities. These data suggest that DHA may influence neural function through activation of an RXR signaling pathway.

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