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Toward a Realistic Model of Mutations Affecting Fitness

Peter D. Keightley and Michael Lynch
Evolution
Vol. 57, No. 3 (Mar., 2003), pp. 683-685
Stable URL: http://www.jstor.org/stable/3094781
Page Count: 3
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Toward a Realistic Model of Mutations Affecting Fitness
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Abstract

Analysis of a recent mutation accumulation (MA) experiment has led to the suggestion that as many as one-half of spontaneous mutations in Arabidopsis are advantageous for fitness. We evaluate this in the light of data from other MA experiments, along with molecular evidence, that suggest the vast majority of new mutations are deleterious.

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