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Differential Regulation of Amyloid-β -Protein mRNA Expression within Hippocampal Neuronal Subpopulations in Alzheimer Disease
Gerald A. Higgins, David A. Lewis, Sina Bahmanyar, Dmitry Goldgaber, D. Carleton Gajdusek, Warren G. Young, John H. Morrison and Michael C. Wilson
Proceedings of the National Academy of Sciences of the United States of America
Vol. 85, No. 4 (Feb. 15, 1988), pp. 1297-1301
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/30986
Page Count: 5
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We have mapped the neuroanatomical distribution of amyloid-β -protein mRNA within neuronal subpopulations of the hippocampal formation in the cynomolgus monkey (Macaca fascicularis), normal aged human, and patients with Alzheimer disease. Amyloid-β -protein mRNA appears to be expressed in all hippocampal neurons, but at different levels of abundance. In the central nervous system of monkey and normal aged human, image analysis shows that neurons of the dentate gyrus and cornu Ammonis fields contain a 2.5-times-greater hybridization signal than is present in neurons of the subiculum and entorhinal cortex. In contrast, in the Alzheimer disease hippocampal formation, the levels of amyloid-β -protein mRNA in the cornu Ammonis field 3 and parasubiculum are equivalent. These findings suggest that within certain neuronal subpopulations cell type-specific regulation of amyloid-β -protein gene expression may be altered in Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America © 1988 National Academy of Sciences