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Noncovalent Functionalization of Carbon Nanotubes for Highly Specific Electronic Biosensors
Robert J. Chen, Sarunya Bangsaruntip, Katerina A. Drouvalakis, Nadine Wong Shi Kam, Moonsub Shim, Yiming Li, Woong Kim, Paul J. Utz and Hongjie Dai
Proceedings of the National Academy of Sciences of the United States of America
Vol. 100, No. 9 (Apr. 29, 2003), pp. 4984-4989
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/3139651
Page Count: 6
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Novel nanomaterials for bioassay applications represent a rapidly progressing field of nanotechnology and nanobiotechnology. Here, we present an exploration of single-walled carbon nanotubes as a platform for investigating surface-protein and protein-protein binding and developing highly specific electronic biomolecule detectors. Nonspecific binding on nanotubes, a phenomenon found with a wide range of proteins, is overcome by immobilization of polyethylene oxide chains. A general approach is then advanced to enable the selective recognition and binding of target proteins by conjugation of their specific receptors to polyethylene oxide-functionalized nanotubes. This scheme, combined with the sensitivity of nanotube electronic devices, enables highly specific electronic sensors for detecting clinically important biomolecules such as antibodies associated with human autoimmune diseases.
Proceedings of the National Academy of Sciences of the United States of America © 2003 National Academy of Sciences