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The Complete Genome Sequence of the Carcinogenic Bacterium Helicobacter hepaticus
Sebastian Suerbaum, Christine Josenhans, Torsten Sterzenbach, Bernd Drescher, Petra Brandt, Monica Bell, Marcus Dröge, Berthold Fartmann, Hans-Peter Fischer, Zhongming Ge, Andrea Hörster, Rudi Holland, Kerstin Klein, Jochen König, Ludwig Macko, George L. Mendz, Gerald Nyakatura, David B. Schauer, Zeli Shen, Jacqueline Weber, Matthias Frosch and James G. Fox
Proceedings of the National Academy of Sciences of the United States of America
Vol. 100, No. 13 (Jun. 24, 2003), pp. 7901-7906
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/3139844
Page Count: 6
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Helicobacter hepaticus causes chronic hepatitis and liver cancer in mice. It is the prototype enterohepatic Helicobacter species and a close relative of Helicobacter pylori, also a recognized carcinogen. Here we report the complete genome sequence of H. hepaticus ATCC51449. H. hepaticus has a circular chromosome of 1,799,146 base pairs, predicted to encode 1,875 proteins. A total of 938, 953, and 821 proteins have orthologs in H. pylori, Campylobacterjejuni, and both pathogens, respectively. H. hepaticus lacks orthologs of most known H. pylori virulence factors, including adhesins, the VacA cytotoxin, and almost all cag pathogenicity island proteins, but has orthologs of the C. jejuni adhesin PEB1 and the cytolethal distending toxin (CDT). The genome contains a 71-kb genomic island (HHGI1) and several genomic islets whose G+C content differs from the rest of the genome. HHGI1 encodes three basic components of a type IV secretion system and other virulence protein homologs, suggesting a role of HHGI1 in pathogenicity. The genomic variability of H. hepaticus was assessed by comparing the genomes of 12 H. hepaticus strains with the sequenced genome by microarray hybridization. Although five strains, including all those known to have caused liver disease, were indistinguishable from ATCC51449, other strains lacked between 85 and 229 genes, including large parts of HHGI1, demonstrating extensive variation of genome content within the species.
Proceedings of the National Academy of Sciences of the United States of America © 2003 National Academy of Sciences