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The Hepatitis C Virus p7 Protein Forms an Ion Channel That Is Inhibited by Long-Alkyl-Chain Iminosugar Derivatives
Davor Pavlović, David C. A. Neville, Olivier Argaud, Baruch Blumberg, Raymond A. Dwek, Wolfgang B. Fischer and Nicole Zitzmann
Proceedings of the National Academy of Sciences of the United States of America
Vol. 100, No. 10 (May 13, 2003), pp. 6104-6108
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/3147549
Page Count: 5
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We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid membranes. HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives, which have antiviral activity against the HCV surrogate bovine viral diarrhea virus. HCV p7 presents a potential target for antiviral therapy.
Proceedings of the National Academy of Sciences of the United States of America © 2003 National Academy of Sciences