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An Erythrocyte-Specific DNA-Binding Factor Recognizes a Regulatory Sequence Common to All Chicken Globin Genes
Todd Evans, Marc Reitman and Gary Felsenfeld
Proceedings of the National Academy of Sciences of the United States of America
Vol. 85, No. 16 (Aug. 15, 1988), pp. 5976-5980
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/32282
Page Count: 5
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We have identified a protein present only in erythroid cells that binds to two adjacent sites within an enhancer region of the chicken β -globin locus. Mutation of the sites, so that binding by the factor can no longer be detected in vitro, leads to a loss of enhancing ability, assayed by transient expression in primary erythrocytes. Binding sites for the erythroid-specific factor (Eryf1) are found within regulatory regions for all chicken globin genes. A strong Eryf1 binding site is also present within the enhancer of at least one human globin gene, and proteins from human erythroid cells (but not HeLa cells) bind to both the chicken and the human sites.
Proceedings of the National Academy of Sciences of the United States of America © 1988 National Academy of Sciences