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Journal Article

Variable Region (Vδ) Gene Segment Most Frequently Utilized in Adult Thymocytes is 3 of the Constant (Cδ) Region

Makio Iwashima, Adrienne Green, Mark M. Davis and Yueh-hsiu Chien
Proceedings of the National Academy of Sciences of the United States of America
Vol. 85, No. 21 (Nov. 1, 1988), pp. 8161-8165
Stable URL: http://www.jstor.org/stable/32590
Page Count: 5

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Topics: Amino acids, Thymocytes, Exons, T lymphocytes, DNA probes, Genetic loci, Complementary DNA, DNA, Genomics, Genes
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Variable Region (Vδ) Gene Segment Most Frequently Utilized in Adult Thymocytes is 3′ of the Constant (Cδ) Region
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Abstract

A variable region (Vδ5) of the T-cell receptor (TcR) δ chain that is preferentially expressed in adult murine thymocytes is located 2.5 kilobases 3 of the constant region (Cδ) element. The Vδ5 coding sequence is in a transcriptional orientation opposite the Jδ (joining region) and Cδ coding elements and rearranges by inversion. The Cδ is divided into four exons, three of which encode amino acids of TcR δ polypeptide, and the fourth comprises the entire 3 untranslated region. In this respect, Cδ resembles Cα rather than Cβ or Cγ.

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