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Variable Region (Vδ) Gene Segment Most Frequently Utilized in Adult Thymocytes is 3′ of the Constant (Cδ) Region
Makio Iwashima, Adrienne Green, Mark M. Davis and Yueh-hsiu Chien
Proceedings of the National Academy of Sciences of the United States of America
Vol. 85, No. 21 (Nov. 1, 1988), pp. 8161-8165
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/32590
Page Count: 5
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A variable region (Vδ5) of the T-cell receptor (TcR) δ chain that is preferentially expressed in adult murine thymocytes is located 2.5 kilobases 3′ of the constant region (Cδ) element. The Vδ5 coding sequence is in a transcriptional orientation opposite the Jδ (joining region) and Cδ coding elements and rearranges by inversion. The Cδ is divided into four exons, three of which encode amino acids of TcR δ polypeptide, and the fourth comprises the entire 3′ untranslated region. In this respect, Cδ resembles Cα rather than Cβ or Cγ.
Proceedings of the National Academy of Sciences of the United States of America © 1988 National Academy of Sciences