Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

Variable Region (Vδ) Gene Segment Most Frequently Utilized in Adult Thymocytes is 3 of the Constant (Cδ) Region

Makio Iwashima, Adrienne Green, Mark M. Davis and Yueh-hsiu Chien
Proceedings of the National Academy of Sciences of the United States of America
Vol. 85, No. 21 (Nov. 1, 1988), pp. 8161-8165
Stable URL: http://www.jstor.org/stable/32590
Page Count: 5
  • Read Online (Free)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Variable Region (Vδ) Gene Segment Most Frequently Utilized in Adult Thymocytes is 3′ of the Constant (Cδ) Region
Preview not available

Abstract

A variable region (Vδ5) of the T-cell receptor (TcR) δ chain that is preferentially expressed in adult murine thymocytes is located 2.5 kilobases 3 of the constant region (Cδ) element. The Vδ5 coding sequence is in a transcriptional orientation opposite the Jδ (joining region) and Cδ coding elements and rearranges by inversion. The Cδ is divided into four exons, three of which encode amino acids of TcR δ polypeptide, and the fourth comprises the entire 3 untranslated region. In this respect, Cδ resembles Cα rather than Cβ or Cγ.

Page Thumbnails

  • Thumbnail: Page 
8161
    8161
  • Thumbnail: Page 
8162
    8162
  • Thumbnail: Page 
8163
    8163
  • Thumbnail: Page 
8164
    8164
  • Thumbnail: Page 
8165
    8165