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Some Mismatch Repair Activities in Escherichia coli

J. Pablo Radicella, Elizabeth A. Clark and Maurice S. Fox
Proceedings of the National Academy of Sciences of the United States of America
Vol. 85, No. 24 (Dec. 15, 1988), pp. 9674-9678
Stable URL: http://www.jstor.org/stable/32699
Page Count: 5
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Some Mismatch Repair Activities in Escherichia coli
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Abstract

Heterozygous bacteriophage λ DNA molecules, whose replication requires mismatch correction of a mutant nucleotide in the transcribed strand, provide an assay for localized mismatch repair in Escherichia coli. We describe two systems: one removes the A in C· A or G· A mismatches and the other removes one or the other C in a C· C mismatch. Mutations disabling the first system result in a mutator phenotype that may be identical to mutY.

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