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A Comparison of the Development of Nippostrongylus brasiliensis in Germ-Free and Conventional Mice
Richard B. Wescott and A. C. Todd
The Journal of Parasitology
Vol. 50, No. 1 (Feb., 1964), pp. 138-143
Stable URL: http://www.jstor.org/stable/3276048
Page Count: 6
You can always find the topics here!Topics: Larvae, Germ free state, Germ free animals, Larval development, Lungs, Experimentation, Infections, Parasite hosts, Sodium, Animals
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Germ-free and conventional mice of similar age and sex were exposed to filariform larvae of Nippostrongylus brasiliensis treated with sodium hypochlorite and antibiotics in four experiments, and in one experiment to filariform larvae which had been given a series of sterile saline washes. In two experiments involving sodium hypochlorite-antibiotic-treated larvae the mice retained their bacteria-free status while contamination occurred with single bacterial species in each of the other three experiments. Fewer adult worms were subsequently recovered from the germ-free and monocontaminated mice than from the conventional controls in all five experiments, and in three experiments these differences were statistically significant. The number of larvae observed in lungs examined 48 hr and 8 days after infection was similar in the germ-free, monocontaminated, and conventional mice, which was interpreted to indicate that the migration of Nippostrongylus takes place similarly through the lungs of both types of hosts, but that a normal bacterial flora in the host can favorably influence the development of adult worms.
The Journal of Parasitology © 1964 The American Society of Parasitologists