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Common Antigens between Adult Schistosoma mansoni and the Laboratory Mouse
Raymond T. Damian
The Journal of Parasitology
Vol. 53, No. 1 (Feb., 1967), pp. 60-64
Stable URL: http://www.jstor.org/stable/3276622
Page Count: 5
You can always find the topics here!Topics: Antigens, Hemolysin proteins, Precipitins, Forssman antigen, Antiserum, Transplantation immunology, Rabbits, Immunization, Hemagglutination, Parasitology
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Common antigens are shown to exist between adult Schistosoma mansoni and a host, the albino mouse. The Ouchterlony technique, in which anti-schistosome rabbit sera are used to compare schistosome extract and mouse serum test antigens, reveals at least four common antigens. Furthermore, rabbit antisera prepared against whole worm homogenates are able to agglutinate mouse erythrocytes. Finally, anti-schistosome sera are found to contain increased levels of sheep hemolysins, indicative of the Forssman antigen in the worm. The Forssman antigen is also known to be present in the mouse, making it another shared antigen. The origins of the common antigens in the worm are still unknown.
The Journal of Parasitology © 1967 The American Society of Parasitologists