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Homocytotropic Antibody Response to the Nematode Nippostrongylus brasiliensis in the Rat: Studies on the Worm Antigen
R. J. M. Wilson
The Journal of Parasitology
Vol. 53, No. 4 (Aug., 1967), pp. 752-762
Stable URL: http://www.jstor.org/stable/3276766
Page Count: 11
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A worm antigen which reacted with rat homocytotropic antibody to N. brasiliensis was demonstrated in culture fluids of adult worms. Production of antigen by adult worms in vitro declined during the first 4 days of maintenance in serum-free medium but was more prolonged in serum-supplemented medium. Six antigens were demonstrated in worm extract using rabbit antisera of restricted immunological specificity. Four of these antigens were present also in culture fluids of adult worms. On preparative agar electrophoresis of worm extract, the antigen which combined with rat homocytotropic antibody to N. brasiliensis migrated towards the cathode with a mobility resembling that of rat γAglobulin. Limited evidence from physicochemical studies suggested that the antigen is a conjugated protein with a molecular weight between 12,000 and 15,000.
The Journal of Parasitology © 1967 The American Society of Parasitologists