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Protective Immunity Produced by the Injection of X-Irradiated Sporozoites of Plasmodium berghei. II. Effects of Radiation on Sporozoites
Jerome P. Vanderberg, Ruth S. Nussenzweig, Harry Most and Colin G. Orton
The Journal of Parasitology
Vol. 54, No. 6 (Dec., 1968), pp. 1175-1180
Stable URL: http://www.jstor.org/stable/3276987
Page Count: 6
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The effects of X-radiation on the infectivity and development of sporozoites of Plasmodium berghei were determined. When susceptible mice were injected with X-irradiated sporozoites, results showed that the higher the dose of radiation, the smaller the percentage of mice that developed patent blood infections. Sporozoites irradiated with more than 10,000 rads failed to produce any blood infections. Small, but apparently mature, exoerythrocytic forms were found in the livers of rats that had been injected with X-irradiated sporozoites. Such forms were more numerous after a low dose of radiation, i.e., 2,000 rads, and were found to persist in the liver for at least 16 days after sporozoite injection. There may be a relationship between the presence of these forms and the protective immunity found in mice inoculated with irradiated sporozoites.
The Journal of Parasitology © 1968 The American Society of Parasitologists