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Resistance Produced in Mice and Rats by Inoculation with Irradiated Trypanosoma rhodesiense

R. E. Duxbury and E. H. Sadun
The Journal of Parasitology
Vol. 55, No. 4 (Aug., 1969), pp. 859-865
DOI: 10.2307/3277231
Stable URL: http://www.jstor.org/stable/3277231
Page Count: 7
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Resistance Produced in Mice and Rats by Inoculation with Irradiated Trypanosoma rhodesiense
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Abstract

Trypanosoma rhodesiense exposed to varied doses of gamma irradiation up to 1,000,000 R were inoculated into mice and rats. Mice inoculated with nonirradiated trypanosomes developed progressive infections and died 3 to 5 days after inoculation. Conversely, all those inoculated with trypanosomes which had been irradiated at doses of more than 20,000 R survived. Complete protection from a challenging infection was induced in mice given 2 or 3 immunizing inoculations. A few of the animals which had received a single immunizing inoculation died after challenge. Similar results were obtained in rats. Fifty-four per cent of the rats which had received a single immunizing inoculation, 85% of those with 2 immunizing inoculations, and 97% of those with 3 immunizing inoculations survived challenge with nonirradiated trypanosomes. Fluorescent antibody tests in immunized rats indicated development of antibodies following inoculation with irradiated trypanosomes. All but 1 of 24 rats survived a second challenge inoculation given 1, 3, or 5 months after the first challenge, but only 1 of 16 rats survived rechallenge after 7 months.

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