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Studies on Delayed (Cellular) Hypersensitivity in Mice Infected with Trichinella spiralis. V. Tests in Recipients Injected with Donor Spleen Cells 1, 3, 7, 14, or 21 Days before Infection
John E. Larsh, Jr., Hilton T. Goulson, Norman F. Weatherly and Elmer F. Chaffee
The Journal of Parasitology
Vol. 56, No. 5 (Oct., 1970), pp. 978-981
Stable URL: http://www.jstor.org/stable/3277518
Page Count: 4
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Three experiments are described. In the first, mice were injected twice into the footpads with an antigen prepared from larvae and mixed in equal volume with Freund's complete adjuvant. After an infection with T. spiralis, these mice harbored significantly fewer adult worms than noninjected controls thereby proving the immunizing effectiveness of the two antigen injections. In the last 2 experiments, donor mice, treated as the experimentais in the first experiment, were killed to collect spleen cells for transfer into recipients, which were challenged with T. spiralis 1, 3, 7, 14, or 21 days after transfer of the cells. The counts of adult worms in these recipients and their respective controls were not significantly different in the case of the 1-day and 3-day groups, but the 7, 14, and 21-day recipients harbored significantly fewer worms than their controls. On the basis of these results, it is concluded that the 2 injections of this antigen preparation produced effects that caused a significant expulsion of worms after challenge, and that the spleen cells from mice treated in this way were responsible for a similar effect noted in recipients challenged as early as 7 days after cell transfer.
The Journal of Parasitology © 1970 The American Society of Parasitologists