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Developmental Physiology of Cestodes. VIII. Inhibition of Ribonucleic Acid Synthesis by Actinomycin-D in Developing Hymenolepis diminuta

Robert I. Bolla and Larry S. Roberts
The Journal of Parasitology
Vol. 56, No. 6 (Dec., 1970), pp. 1151-1158
DOI: 10.2307/3277561
Stable URL: http://www.jstor.org/stable/3277561
Page Count: 8
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Developmental Physiology of Cestodes. VIII. Inhibition of Ribonucleic Acid Synthesis by Actinomycin-D in Developing Hymenolepis diminuta
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Abstract

The uptake and incorporation of actinomycin-D by Hymenolepis diminuta (Cestoda:Cyclophyllidea) was measured. Treatment of very young worms (4 days after infection of the host) with concentrations of this drug of 9.5 µm to 15.9 µm inhibited incorporation of uridine into RNA by greater than 90%. Synthesis of DNA-dependent RNA was 100% inhibited. Inhibition was greater in the germinative and immature regions than in the mature proglottids of the strobila of 8-day-old worms. There was no effect of the drug on incorporation of thymidine into DNA. The data support the use of actinomycin-D as a tool in studying gene activity during development of H. diminuta.

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