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Comparative Activity of 29 Known Anthelmintics under Standardized Drug-Diet and Gavage Medication Regimens against Four Helminth Species in Mice
Gerald Brody and Thomas E. Elward
The Journal of Parasitology
Vol. 57, No. 5 (Oct., 1971), pp. 1068-1077
Stable URL: http://www.jstor.org/stable/3277866
Page Count: 10
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A group of 29 reference anthelmintics (21 aromatic-heterocyclic and 8 organophosphate compounds) were evaluated for antiparasitic activity against 4 mouse helminths (Nematospiroides dubius, Hymenolepis nana, Syphacia obvelata, and Aspiculuris tetraptera) at an initial concentration of 1,000 ppm in the diet for 18 days. EC50 and EC90 values were determined for each of the anthelmintics administered in this 18-day drug-diet regimen against each of the 4 test helminths. Parbendazole was the only compound exhibiting activity against all 4 test helminths. Eight compounds were active against N. dubius, with pyrantel and dl- and l-tetramisole exhibiting the greatest activity. Bunamidine was the most active of 7 reference anticestode agents. Twenty-one anthelmintics were active against S. obvelata, compared with 13 active against A. tetraptera. In general, A. tetraptera appeared to be more resistant to the aromatic-heterocyclic compounds than to the organophosphates. A few experiments were carried out in which the 29 compounds were examined for anthelmintic activity against mature infections of the 4 test helminths, using a 3-day gavage regimen at an initial dose of 200 mg/kg/day. Definite differences were observed in the effectiveness of a number of the anthelmintics in the 2 medication regimens.
The Journal of Parasitology © 1971 The American Society of Parasitologists