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Serology of the Cercarienhüllen Reaktion of Schistosoma mansoni
Walter Michael Kemp
The Journal of Parasitology
Vol. 58, No. 4 (Aug., 1972), pp. 686-692
Stable URL: http://www.jstor.org/stable/3278291
Page Count: 7
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Serological studies proved the Cercarienhüllen Reaktion (CHR) to be specific, in that the reaction was absent in normal serum and could only be absorbed out of antiserum by cercarial antigen. Observations of titer levels showed primary and secondary responses characteristic of antibody. Serum fractionation and the subsequent testing of fractionated serum by immunoelectrophoresis showed the CHR serum factor to be antibody of the class IgG. Immunofluorescent tests verified the results of the serum fractionation studies. The role of complement in the reaction was proven by its removal by heating and its subsequent addition to the form of guinea pig complement or homologous normal serum.
The Journal of Parasitology © 1972 The American Society of Parasitologists