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Biochemical Alterations in Organs of Mice Infected with Hymenolepis microstoma, the Mouse Bile Duct Tapeworm
Peter W. Pappas
The Journal of Parasitology
Vol. 64, No. 2 (Apr., 1978), pp. 265-272
Stable URL: http://www.jstor.org/stable/3279670
Page Count: 8
You can always find the topics here!Topics: Bile ducts, Liver, Spleen, Collagens, Memory interference, Biochemistry, Small intestine, Infections, RNA, DNA
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Livers, spleens, small intestines, and bile ducts of control CF-1 female mice and mice infected with Hymenolepis microstoma were analyzed quantitatively for glucose, glycogen, RNA, DNA, protein, and hydroxyproline (as a measure of collagen). The following changes were noted in the relative composition of organs from infected mice: (1) a decrease in hepatic glycogen and glucose beginning days 12 and 8 postinfection (PI), respectively; (2) an increase in spleen protein beginning day 15 PI; (3) a decrease in small intestine RNA beginning day 20 PI; (4) a decrease in bile duct glycogen beginning day 8 PI; (5) a decrease in bile duct and spleen hydroxyproline beginning days 12 and 20 PI, respectively. Incorporation rates or radioactive thymidine, uridine, methionine, and proline were determined in these same organs to assess DNA, RNA, protein, and collagen synthesis, respectively, and the following changes were noted: (1) a decrease in uridine incorporation in the small intestine and spleen beginning days 15 and 20 PI, respectively; (2) an increase in uridine incorporation in the liver between days 8 and 20 PI; (3) an increase in uridine incorporation in the bile duct between days 8 and 12 PI, followed by a decrease in incorporation between days 20 and 50 PI; (4) an increase in thymidine incorporation in the spleen, liver, and bile duct between days 8 and 20 PI, 8 and 15 PI, and 6 and 12 PI, respectively; (5) an increase in methionine incorporation in the spleen and liver between days 8 and 15 PI; (6) an increase in methionine incorporation in the bile duct between days 8 and 12 PI, followed by a decrease in incorporation between days 20 and 50 PI; (7) an increase in proline incorporation in the spleen, liver, and bile duct between days 15 and 50 PI, 8 and 15 PI, and 8 and 50 PI, respectively. The data indicate that all organs undergo significant hyperplasia (as opposed to hypertrophy), and that deposition of collagen (fibrosis) does not make a significant contribution to the process of organ growth.
The Journal of Parasitology © 1978 The American Society of Parasitologists