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Histopathology of Hepatic and Pulmonary Granulomata Experimentally Induced with Eggs of Schistosoma mansoni

Luke D. Edungbola and Everett L. Schiller
The Journal of Parasitology
Vol. 65, No. 2 (Apr., 1979), pp. 253-261
DOI: 10.2307/3280158
Stable URL: http://www.jstor.org/stable/3280158
Page Count: 9
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Histopathology of Hepatic and Pulmonary Granulomata Experimentally Induced with Eggs of Schistosoma mansoni
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Abstract

Hepatic granulomata were experimentally induced in previously unexposed white mice, albino rats and golden hamsters by injecting viable exogenous eggs of Schistosoma mansoni via the mesenterico-portal system. Histopathologic studies of livers of these animals showed that the lesions were similar to those in infections resulting from exposure to cercariae as occurs naturally in Mansonian schistosomiasis. Comparable observations made of the lungs of animals that had received egg injections via their tail veins, showed striking differences with respect to timing of the occurrence of various histopathologic stages, mean size of granulomata, cellular composition and pathologic manifestations.

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