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Effect of Sodium Cyanate on Plasmodium falciparum In vitro
R. L. Nagel, C. Raventos, H. B. Tanowitz and M. Wittner
The Journal of Parasitology
Vol. 66, No. 3 (Jun., 1980), pp. 483-487
Stable URL: http://www.jstor.org/stable/3280752
Page Count: 5
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Sodium cyanate at concentrations as low as 0.5 mM inhibited the growth of Plasmodium falciparum (FCR-3 Strain) utilizing the Trager-Jensen continuous culture system. At concentrations higher than 1 mM, the parasites were irreversibly destroyed. Utilizing synchronized cultures, the relative susceptibilities of early and late trophozoite forms were examined, and it was found that both developmental forms were equally susceptible to the action of cyanate. Pretreatment of red cells with sodium cyanate prior to infection did not alter the intracellular growth of the parasite. Consequently, the effect of the drug is likely to be on the parasite per se rather than the red cell. The mechanism of action is probably the carbamylation of essential, parasite proteins that eventually impair growth and/or function. Published pharmacological studies in humans would predict that the level of cyanate at which growth inhibition occurs in vitro can be achieved in vivo and that the adverse effects will likely be minimal for short treatment periods.
The Journal of Parasitology © 1980 The American Society of Parasitologists