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Therapeutic Efficacy of Several Nitroimidazoles for Experimental Trypanosoma cruzi Infections in Mice
C. M. Malanga, J. Conroy and A. C. Cuckler
The Journal of Parasitology
Vol. 67, No. 1 (Feb., 1981), pp. 35-40
Stable URL: http://www.jstor.org/stable/3280774
Page Count: 6
You can always find the topics here!Topics: Inoculation, Parasitemia, Blood, Dosage, Heart, Infections, Myocarditis, Patents, Medical treatment, Cardiomyopathies
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Several, substituted 5-nitroimidazole analogs were compared for efficacy against experimental Trypanosoma cruzi infections in mice. These studies indicated that the efficacy of substituted 5- nitroimidazoles varies significantly with minor changes in structure. One compound, 3-(1-methyl-5-nitroimidazol-2-yl)-3α,4,5,6,7,7α -hexahydro-1,2-benzisoxazole, MK-436, was the most potent in eliminating parasitemia and myocardiopathy. Other 5-nitroimidazole analogs had varying degrees of efficacy.
The Journal of Parasitology © 1981 The American Society of Parasitologists