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Therapeutic Efficacy of Several Nitroimidazoles for Experimental Trypanosoma cruzi Infections in Mice

C. M. Malanga, J. Conroy and A. C. Cuckler
The Journal of Parasitology
Vol. 67, No. 1 (Feb., 1981), pp. 35-40
DOI: 10.2307/3280774
Stable URL: http://www.jstor.org/stable/3280774
Page Count: 6
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Therapeutic Efficacy of Several Nitroimidazoles for Experimental Trypanosoma cruzi Infections in Mice
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Abstract

Several, substituted 5-nitroimidazole analogs were compared for efficacy against experimental Trypanosoma cruzi infections in mice. These studies indicated that the efficacy of substituted 5- nitroimidazoles varies significantly with minor changes in structure. One compound, 3-(1-methyl-5-nitroimidazol-2-yl)-3α,4,5,6,7,7α -hexahydro-1,2-benzisoxazole, MK-436, was the most potent in eliminating parasitemia and myocardiopathy. Other 5-nitroimidazole analogs had varying degrees of efficacy.

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