Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If you need an accessible version of this item please contact JSTOR User Support

Observations on Two Strains of Plasmodium falciparum from Haiti in Aotus Monkeys

William E. Collins, William Chin, McWilson Warren, Alan Y. Huong, Geoffrey M. Jeffery and Jimmie C. Skinner
The Journal of Parasitology
Vol. 68, No. 4 (Aug., 1982), pp. 657-667
DOI: 10.2307/3280925
Stable URL: http://www.jstor.org/stable/3280925
Page Count: 11
  • Read Online (Free)
  • Cite this Item
If you need an accessible version of this item please contact JSTOR User Support
Observations on Two Strains of Plasmodium falciparum from Haiti in Aotus Monkeys
Preview not available

Abstract

Two strains of Plasmodium falciparum originating in Haiti were studied in the Aotus monkey. The Haitian I/CDC strain was first adapted to in vitro cultivation and subsequently inoculated into monkeys. The Haitian III/CDC strain was inoculated directly from a human patient into the Aotus monkey. The strains varied in their levels of pathogenicity to the animals. The Haitian I/CDC strain was highly virulent in six splenectomized animals; in one intact animal, the infection could be controlled but not eliminated with periodic doses of quinine and chloroquine. After subsequent splenectomy, the animal developed high parasitemias and died. No gametocytes developed in any of the Haitian I infections. The Haitian III strain was lethal to five of the 14 splenectomized monkeys inoculated, but some were able to control their infections without drug intervention. Gametocytes developed in all infections that persisted for an adequate length of time, and infections of mosquitoes were obtained both during the primary attack and the first recrudescence of the parasitemia. Of the mosquitoes tested, Anopheles freeborni was most susceptible to infection, followed by An. culicifacies, An. dirus, An. maculatus, and An. albimanus. The Haitian III strain was successfully transmitted to four other splenectomized Aotus monkeys via sporozoite inoculation using An. freeborni.

Page Thumbnails

  • Thumbnail: Page 
657
    657
  • Thumbnail: Page 
658
    658
  • Thumbnail: Page 
659
    659
  • Thumbnail: Page 
660
    660
  • Thumbnail: Page 
661
    661
  • Thumbnail: Page 
662
    662
  • Thumbnail: Page 
663
    663
  • Thumbnail: Page 
664
    664
  • Thumbnail: Page 
665
    665
  • Thumbnail: Page 
666
    666
  • Thumbnail: Page 
667
    667