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Temperature-Dependent Fatty Acyl Group Changes in Phospholipids of 37 C-Adapted Leishmania donovani Promastigotes
D. H. Beach, G. G. Holz, Jr., L. H. Semprevivo and B. M. Honigberg
The Journal of Parasitology
Vol. 68, No. 6 (Dec., 1982), pp. 1004-1009
Stable URL: http://www.jstor.org/stable/3281083
Page Count: 6
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Promastigotes of Lesihmania donovani, Stock 3S, adapted to grow in a biphasic medium at 37 C, by step-wise increases in incubation temperature from 25 C, showed marked reductions in the amounts of C18, C20, and C22 polyunsaturated fatty acyl groups present in membrane phospholipids of the 25 C-adapted flagellates. These changes may be considered a homeoviscous adaptation directed at maintenance of membrane bilayer lipids in a liquid-crystalline state appropriate to normal performance of membrane barrier functions. Such an adaptive decrease in fatty acyl groups, which contribute to lipid bilayer fluidity, argues against the concept that the adoption of an intracellular habitat by the amastigote stage of leishmanias is necessary to protect it from the consequences of temperature-induced membrane disorder and consequent loss of control of permeability.
The Journal of Parasitology © 1982 The American Society of Parasitologists