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Stage-Specific Inhibitory Effect of Cyclic AMP on Asexual Maturation and Gametocyte Formation of Plasmodium falciparum

Joseph Inselburg
The Journal of Parasitology
Vol. 69, No. 3 (Jun., 1983), pp. 592-597
DOI: 10.2307/3281375
Stable URL: http://www.jstor.org/stable/3281375
Page Count: 6
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Stage-Specific Inhibitory Effect of Cyclic AMP on Asexual Maturation and Gametocyte Formation of Plasmodium falciparum
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Abstract

The effect of cyclic AMP on asexual maturation and gametocyte formation of Plasmodium falciparum grown in vitro was examined over a wide range of concentrations. Cyclic AMP inhibited both processes in a stage-specific manner. Asexual maturation was inhibited from shortly after parasite entry into the red cell through the ring stage. However, trophozoites and schizonts matured normally in the presence of cyclic AMP and produced infectious merozoites. Gametocyte formation was inhibited by 95% when 1.0 mM cyclic AMP was added to synchronously growing parasites in the ring stage of development but was only inhibited by 15% when added in the trophozoite or schizont stages. Cyclic AMP was not found to increase gametocyte formation over a wide range of concentrations.

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