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Infection and Transmission Studies with the N-3 Strain of Plasmodium fieldi in the Macaca mulatta Monkey

William E. Collins, Jimmie C. Skinner, Peggy S. Stanfill, Bettye B. Sutton and Alan Y. Huong
The Journal of Parasitology
Vol. 70, No. 3 (Jun., 1984), pp. 422-427
DOI: 10.2307/3281575
Stable URL: http://www.jstor.org/stable/3281575
Page Count: 6
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Infection and Transmission Studies with the N-3 Strain of Plasmodium fieldi in the Macaca mulatta Monkey
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Abstract

Seven different anophelines-Anopheles freeborni, An. dirus, An. maculatus, An. atroparvus, An. stephensi, An. albimanus, and An. quadrimaculatus-were shown to be susceptible to infection with the N-3 strain of Plasmodium fieldi. Transmission was obtained via the bites of An. dirus, An. stephensi, and An. maculatus mosquitoes to Macaca mulatta monkeys. Sporozoites dissected from An. freeborni were also shown to be infectious. Anopheles dirus and An. stephensi were the most suitable mosquitoes for transmission studies. Prepatent periods in M. mulatta monkeys following sporozoite inoculation ranged from 9 to 18 days with a mean of 12.3 days. Maximum parasitemias in intact animals following sporozoite inoculation ranged from 5,460 to 32,800 per mm3. Mean maximum parasitemia in splenectomized monkeys inoculated with parasitized blood was 146,000 per mm3.

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