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Hymenolepis microstoma: Histopathological Changes in Mice Maintained at Different Environmental Temperatures
Marie Novak, G. McTavish and W. S. Evans
The Journal of Parasitology
Vol. 71, No. 6 (Dec., 1985), pp. 735-741
Stable URL: http://www.jstor.org/stable/3281705
Page Count: 7
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Livers of uninfected mice maintained at 5 C did not differ histologically from mice kept at 21 C, but the hepatocytes of mice kept at 35 C were depleted of glycogen. Regardless of temperature, infection with a single Hymenolepis microstoma induced inflammatory changes in the livers of all mice. However, the degree of histopathology was less in mice kept at 21 C than in mice at 5 C or 35 C. Infected mice in the hot and cold environments developed necrotic lesions in their liver parenchyma. Livers of mice kept at 35 C contained many foreign body giant cells. Temperature had no histological effect on the common bile duct, but in all infected mice there was a pronounced thickening of the bile duct wall due to intensive infiltration of the submucosa with fibrous connective elements and inflammatory leucocytes.
The Journal of Parasitology © 1985 The American Society of Parasitologists