You are not currently logged in.
Access JSTOR through your library or other institution:
If You Use a Screen ReaderThis content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Efficacy of Ivermectin in Hookworms as Examined in Ancylostoma caninum Infections
Cheng-i Wang, Xian X. Huang, Yue Q. Zhang, Quang Y. Yen and Yan Wen
The Journal of Parasitology
Vol. 75, No. 3 (Jun., 1989), pp. 373-377
Stable URL: http://www.jstor.org/stable/3282591
Page Count: 5
You can always find the topics here!Topics: Dosage, Larvae, Infections, Eggs, Feces, Body weight, Ova, Female animals, Uterine tissue, Hookworm infections
Were these topics helpful?See something inaccurate? Let us know!
Select the topics that are inaccurate.
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Preview not available
Single oral doses of ivermectin were given to dogs with moderate or heavy infections of Ancylostoma caninum (egg counts ranging from 7,100 to 41,700 eggs/g feces) at 100, 50, 30, or 10 µg/kg body weight. Each of these dosages was effective in clearing the infection completely, so that numerous worms were passed in the feces on days 1-3, but no worm was recovered from the intestinal tract at necropsy on day 4 after treatment. In contrast, an average of 178 worms per dog was recovered at necropsy from the vehicle-treated control and the untreated animals. Albendazole, a known anti-hookworm agent, even in a dose of 400 mg, eliminated only 21-65% of the worms harbored by the infected animals. No untoward reaction to ivermectin or significant pathological change was noted in the experimental animals. In vitro experiments demonstrated that ivermectin: (1) was highly detrimental to actively motile adult worms in concentrations greater than 5.60 µg/ml; (2) was detrimental to eggs inside the uterine tissue of female worms in dosages at or greater than 10 µg/kg body weight; and (3) killed infected larvae in concentrations as low as 0.0025 µg/ml.
The Journal of Parasitology © 1989 The American Society of Parasitologists