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Efficacy of Ivermectin in Hookworms as Examined in Ancylostoma caninum Infections
Cheng-i Wang, Xian X. Huang, Yue Q. Zhang, Quang Y. Yen and Yan Wen
The Journal of Parasitology
Vol. 75, No. 3 (Jun., 1989), pp. 373-377
Stable URL: http://www.jstor.org/stable/3282591
Page Count: 5
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Single oral doses of ivermectin were given to dogs with moderate or heavy infections of Ancylostoma caninum (egg counts ranging from 7,100 to 41,700 eggs/g feces) at 100, 50, 30, or 10 µg/kg body weight. Each of these dosages was effective in clearing the infection completely, so that numerous worms were passed in the feces on days 1-3, but no worm was recovered from the intestinal tract at necropsy on day 4 after treatment. In contrast, an average of 178 worms per dog was recovered at necropsy from the vehicle-treated control and the untreated animals. Albendazole, a known anti-hookworm agent, even in a dose of 400 mg, eliminated only 21-65% of the worms harbored by the infected animals. No untoward reaction to ivermectin or significant pathological change was noted in the experimental animals. In vitro experiments demonstrated that ivermectin: (1) was highly detrimental to actively motile adult worms in concentrations greater than 5.60 µg/ml; (2) was detrimental to eggs inside the uterine tissue of female worms in dosages at or greater than 10 µg/kg body weight; and (3) killed infected larvae in concentrations as low as 0.0025 µg/ml.
The Journal of Parasitology © 1989 The American Society of Parasitologists