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Journal Article

Ivermectin Binding Sites in Sensitive and Resistant Haemonchus contortus

Susan P. Rohrer, Elizabeth T. Birzin, Clint H. Eary, James M. Schaeffer and Wesley L. Shoop
The Journal of Parasitology
Vol. 80, No. 3 (Jun., 1994), pp. 493-497
DOI: 10.2307/3283426
Stable URL: http://www.jstor.org/stable/3283426
Page Count: 5
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Ivermectin Binding Sites in Sensitive and Resistant Haemonchus contortus
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Abstract

Membranes from both ivermectin-sensitive and -resistant Haemonchus contortus L3 larvae were examined for the presence of high affinity [3H]ivermectin binding sites. Both tissue preparations displayed high affinity drug binding sites (Kd = 0.13 nM). Receptor density (Bmax = 0.4 pmol/mg) was the same in both the sensitive and resistant nematodes suggesting that target site modification was not involved in the development of drug resistance in this particular strain of H. contortus. The H. contortus ivermectin binding site appeared to be similar to the well characterized Caenorhabditis elegans ivermectin binding site with respect to affinity for ivermectin and receptor density.

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