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Shift from an Early Protective TH1-Type Immune Response to a Late Permissive TH2-Type Response in Murine Cysticercosis (Taenia crassiceps)

Luis I. Terrazas, Rafael Bojalil, Tzipe Govezensky and Carlos Larralde
The Journal of Parasitology
Vol. 84, No. 1 (Feb., 1998), pp. 74-81
DOI: 10.2307/3284533
Stable URL: http://www.jstor.org/stable/3284533
Page Count: 8
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Shift from an Early Protective TH1-Type Immune Response to a Late Permissive TH2-Type Response in Murine Cysticercosis (Taenia crassiceps)
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Abstract

In early stages of experimental murine cysticercosis caused by Taenia crassiceps, there is a clear but transient Th1-type immune response (characterized by high levels of interleukin [IL]-2, interferon-γ, concanavalin A, and antigen specific response, delayed-type hypersensitivity, and immunoglobulin [Ig]G2a antibodies) that associates with a low rate of parasite reproduction. As time of infection progresses an energic and more permanent Th2-type response follows (characterized by high levels of IL-4, IL-6, IL-10, IgG2b, and IgGl antibodies) that in turn associates with an increment in the rate of parasite reproduction. The sequential activation of Thl-type and Th2-type responses in murine cysticercosis would appear to favor progressively parasite reproduction, explaining the long time residence and the massive parasite intensity reached in chronic infections.

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