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Inositolphospholipid-Linked Glutamate Receptors Mediate Cerebellar Parallel-Fiber--Purkinje-Cell Synaptic Transmission
Craig D. Blackstone, Surachai Supattapone and Solomon H. Snyder
Proceedings of the National Academy of Sciences of the United States of America
Vol. 86, No. 11 (Jun. 1, 1989), pp. 4316-4320
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/33678
Page Count: 5
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In slices of adult rat cerebellum inositolphospholipid turnover is stimulated markedly by glutamate and its rigid analogues quisqualate and ibotenate. The drug and amino acid specificity of the response reflects a quisqualate-preferring excitatory amino acid receptor. The absence of glutamate-enhanced inositolphospholipid turnover in mice with Purkinjecell degeneration indicates that the inositolphospholipid-linked quisqualate receptor mediates parallel fiber--Purkinje cell synaptic transmission. The quantitative prominence of this synapse accounts for the massive enrichment of elements of the inositolphospholipid system in cerebellar Purkinje cells.
Proceedings of the National Academy of Sciences of the United States of America © 1989 National Academy of Sciences