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Inositolphospholipid-Linked Glutamate Receptors Mediate Cerebellar Parallel-Fiber--Purkinje-Cell Synaptic Transmission

Craig D. Blackstone, Surachai Supattapone and Solomon H. Snyder
Proceedings of the National Academy of Sciences of the United States of America
Vol. 86, No. 11 (Jun. 1, 1989), pp. 4316-4320
Stable URL: http://www.jstor.org/stable/33678
Page Count: 5
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Inositolphospholipid-Linked Glutamate Receptors Mediate Cerebellar Parallel-Fiber--Purkinje-Cell Synaptic Transmission
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Abstract

In slices of adult rat cerebellum inositolphospholipid turnover is stimulated markedly by glutamate and its rigid analogues quisqualate and ibotenate. The drug and amino acid specificity of the response reflects a quisqualate-preferring excitatory amino acid receptor. The absence of glutamate-enhanced inositolphospholipid turnover in mice with Purkinjecell degeneration indicates that the inositolphospholipid-linked quisqualate receptor mediates parallel fiber--Purkinje cell synaptic transmission. The quantitative prominence of this synapse accounts for the massive enrichment of elements of the inositolphospholipid system in cerebellar Purkinje cells.

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