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Import of Cytochrome c into Mitochondria: Reduction of Heme, Mediated by NADH and Flavin Nucleotides, is Obligatory for Its Covalent Linkage to Apocytochrome c

Donald W. Nicholson and Walter Neupert
Proceedings of the National Academy of Sciences of the United States of America
Vol. 86, No. 12 (Jun. 15, 1989), pp. 4340-4344
Stable URL: http://www.jstor.org/stable/33685
Page Count: 5
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Import of Cytochrome c into Mitochondria: Reduction of Heme, Mediated by NADH and Flavin Nucleotides, is Obligatory for Its Covalent Linkage to Apocytochrome c
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Abstract

The covalent attachment of heme to apocytochrome c, and therefore the import of cytochrome c into mitochondria, is dependent on both NADH plus a cytosolic cofactor that has been identified to be FMN or FAD. NADH in concert with flavin nucleotides mediates the reduction of heme. Heme in the reduced state is a prerequisite for its covalent attachment to apocytochrome c by the enzyme cytochrome c heme lyase and thus for subsequent translocation of cytochrome c across the outer mitochondrial membrane during import.

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