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Notch Is Required for Long-Term Memory in Drosophila
Asaf Presente, Randy S. Boyles, Christine N. Serway, J. Steven de Belle, Andrew J. Andres and Howard A. Nash
Proceedings of the National Academy of Sciences of the United States of America
Vol. 101, No. 6 (Feb. 10, 2004), pp. 1764-1768
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/3371264
Page Count: 5
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A role for Notch in the elaboration of existing neural processes is emerging that is distinct from the increasingly well understood function of this gene in binary cell-fate decisions. Several research groups, by using a variety of organisms, have shown that Notch is important in the development of neural ultrastructure. Simultaneously, Presenilin (Psn) was identified both as a key mediator of Notch signaling and as a site of genetic lesions that cause early-onset Alzheimer's disease. Here we demonstrate that Notch loss of function produces memory deficits in Drosophila melanogaster. The effects are specific to long-term memory, which is thought to depend on ultrastructural remodeling. We propose that Notch plays an important role in the neural plasticity underlying consolidated memory.
Proceedings of the National Academy of Sciences of the United States of America © 2004 National Academy of Sciences