You are not currently logged in.
Access your personal account or get JSTOR access through your library or other institution:
If You Use a Screen ReaderThis content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Spontaneous Proliferation, a Response of Naïve CD4 T Cells Determined by the Diversity of the Memory Cell Repertoire
Booki Min, Gilles Foucras, Martin Meier-Schellersheim and William E. Paul
Proceedings of the National Academy of Sciences of the United States of America
Vol. 101, No. 11 (Mar. 16, 2004), pp. 3874-3879
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/3371453
Page Count: 6
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Preview not available
T cell numbers are maintained within narrow ranges in vivo. Introduction of naïve cells into lymphopenic environments results in proliferation and differentiation driven by the recognition of peptide/MHC complexes and by cytokine signaling. This process, often described as homeostatic proliferation, is here referred to as spontaneous proliferation. We show that, although the presence of memory CD4 T cells of broad repertoire efficiently inhibits proliferation/differentiation of naïve CD4 T cells, a memory population of similar size comprised of cells with a repertoire of limited diversity fails to do so, implying that cells of a given specificity prevent responses of cells of the same or related specificity. This finding suggests that the immune system has evolved mechanisms to attain a memory cell repertoire of great diversity independently of foreign antigens.
Proceedings of the National Academy of Sciences of the United States of America © 2004 National Academy of Sciences