Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

Spontaneous Proliferation, a Response of Naïve CD4 T Cells Determined by the Diversity of the Memory Cell Repertoire

Booki Min, Gilles Foucras, Martin Meier-Schellersheim and William E. Paul
Proceedings of the National Academy of Sciences of the United States of America
Vol. 101, No. 11 (Mar. 16, 2004), pp. 3874-3879
Stable URL: http://www.jstor.org/stable/3371453
Page Count: 6
  • Read Online (Free)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Spontaneous Proliferation, a Response of Naïve CD4 T Cells Determined by the Diversity of the Memory Cell Repertoire
Preview not available

Abstract

T cell numbers are maintained within narrow ranges in vivo. Introduction of naïve cells into lymphopenic environments results in proliferation and differentiation driven by the recognition of peptide/MHC complexes and by cytokine signaling. This process, often described as homeostatic proliferation, is here referred to as spontaneous proliferation. We show that, although the presence of memory CD4 T cells of broad repertoire efficiently inhibits proliferation/differentiation of naïve CD4 T cells, a memory population of similar size comprised of cells with a repertoire of limited diversity fails to do so, implying that cells of a given specificity prevent responses of cells of the same or related specificity. This finding suggests that the immune system has evolved mechanisms to attain a memory cell repertoire of great diversity independently of foreign antigens.

Page Thumbnails

  • Thumbnail: Page 
[3874]
    [3874]
  • Thumbnail: Page 
3875
    3875
  • Thumbnail: Page 
3876
    3876
  • Thumbnail: Page 
3877
    3877
  • Thumbnail: Page 
3878
    3878
  • Thumbnail: Page 
3879
    3879