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Spontaneous Proliferation, a Response of Naïve CD4 T Cells Determined by the Diversity of the Memory Cell Repertoire
Booki Min, Gilles Foucras, Martin Meier-Schellersheim and William E. Paul
Proceedings of the National Academy of Sciences of the United States of America
Vol. 101, No. 11 (Mar. 16, 2004), pp. 3874-3879
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/3371453
Page Count: 6
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T cell numbers are maintained within narrow ranges in vivo. Introduction of naïve cells into lymphopenic environments results in proliferation and differentiation driven by the recognition of peptide/MHC complexes and by cytokine signaling. This process, often described as homeostatic proliferation, is here referred to as spontaneous proliferation. We show that, although the presence of memory CD4 T cells of broad repertoire efficiently inhibits proliferation/differentiation of naïve CD4 T cells, a memory population of similar size comprised of cells with a repertoire of limited diversity fails to do so, implying that cells of a given specificity prevent responses of cells of the same or related specificity. This finding suggests that the immune system has evolved mechanisms to attain a memory cell repertoire of great diversity independently of foreign antigens.
Proceedings of the National Academy of Sciences of the United States of America © 2004 National Academy of Sciences