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Defective Virus is Associated with Induction of Murine Retrovirus-Induced Immunodeficiency Syndrome

Sisir K. Chattopadhyay, Herbert C. Morse, Masahiko Makino, Sandra K. Ruscetti and Janet W. Hartley
Proceedings of the National Academy of Sciences of the United States of America
Vol. 86, No. 10 (May 15, 1989), pp. 3862-3866
Stable URL: http://www.jstor.org/stable/33976
Page Count: 5
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Defective Virus is Associated with Induction of Murine Retrovirus-Induced Immunodeficiency Syndrome
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Abstract

C57BL/6 mice infected with a mixture of murine leukemia viruses (MuLV) develop a syndrome characterized by lymphoproliferation and profound immunodeficiency. Analyses of this viral mixture (LP-BM5 MuLV) showed that it includes replication-competent ecotropic and mink cell focus-inducing MuLV and defective viruses with genome sizes of 3.8-6.5 kilobases. The ecotropic and mink cell focus-inducing MuLV biologically cloned from the mixture did not induce disease, whereas viral preparations containing the ecotropic MuLV and 4.8-kilobase defective virus were active. Cells producing the 4.8-kilobase defective virus expressed an unusual gag-encoded polyprotein of Mr 60,000.

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